Linagliptin Tablets is used for ‘type 2 diabetes’ in adults if the disease cannot be adequately controlled with one oral anti-diabetic medicine (metformin or sulphonylureas) or diet and exercise alone. Linagliptin Tablets may be used together with other anti- diabetic medicines e.g. metformin, sulphonylureas (e.g. glimepiride, glipizide), empagliflozin, or insulin.

It is important to keep following the advice about diet and exercise that you have been given by your doctor or nurse.

Always take this medicine exactly as your doctor has told you. Check with your doctor or pharmacist if you are not sure.

The recommended dose of Linagliptin Tablets is one 5 mg tablet once a day.

You can take Linagliptin Tablets with or without food. Your doctor may prescribe Linagliptin Tablets together with another oral anti-diabetic medicine.

Remember to take all medicines as directed by your doctor to achieve the best results for your health.

Tell your doctor or pharmacist if you are taking, have recently taken or

might take any other medicines. In particular, you should tell your doctor if you are using medicines containing any of the following

active substances:

• Carbamazepine, phenobarbital or phenytoin.
• Rifampicin

Do not take Linagliptin Tablets

• if you are allergic to Linagliptin

Warnings and precautions

Talk to your doctor, pharmacist or nurse before taking Linagliptin

Tablets if you:

• have type 1 diabetes (your body does not produce any insulin) or diabetic ketoacidosis (a complication of diabetes with high blood sugar, rapid weight loss, nausea or vomiting). Linagliptin Tablets should not be used to treat these conditions.
• are taking an anti-diabetic medicine known as a ‘sulphonylurea’ (e.g. glimepiride, glipizide), your doctor may want to reduce your dose of sulphonylurea when you take it together with Linagliptin Tablets to avoid your blood sugar going too low.
• have had allergic reactions to any other medicines that you take to control the amount of sugar in your blood.
• have or have had a disease of the pancreas. If you have symptoms of acute pancreatitis, like persistent, severe stomach ache (abdominal pain), you should consult your doctor.
• If you encounter blistering of the skin it may be a sign for a condition called bullous pemphigoid. Your doctor may ask you to stop Linagliptin Tablets.
• Diabetic skin lesions are a common complication of diabetes. You are advised to follow the recommendations for skin and foot care that you are given by your doctor or nurse

Children and adolescents:

Linagliptin Tablets is not recommended for children and adolescents under 18 years.

Pregnancy and breast-feeding:

If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.

It is unknown if Linagliptin Tablets is harmful to the unborn child. Therefore, it is preferable to avoid using Linagliptin Tablets if you are pregnant. It is not known if Linagliptin Tablets passes into human breast milk. A decision must be made by your doctor whether to discontinue breast-feeding or to discontinue/abstain from Linagliptin Tablets therapy.

Driving and using machines

Linagliptin Tablets has no or negligible influence on the ability to drive and use machines.

Taking Linagliptin Tablets in combination with medicines called sulphonylureas and/or insulin can cause too low blood sugar levels (hypoglycemia), which may affect your ability to drive and use

machines or work without a safe foothold.

However, more frequent blood glucose testing might be recommended to minimize the risk for hypoglycemia, especially when Linagliptin Tablets is combined with sulphonylurea and/or insulin.