CEFODEL – dry syrup: Each 5 ml of reconstituted suspension contains Cefpodoxime Proxetil USP equivalent to Cefpodoxime 50 mg. CEFODEL – 100 dry syrup: Each 5 ml of reconstituted suspension contains Cefpodoxime Proxetil USP equivalent to Cefpodoxime 100 mg. CEFODEL 200mg: Each film coated tablet contains Cafpodoxime Proxetil 200 mg.
Cefpodoxime can be used to treat:
Cefpodoxime is an oral third-generation cephalosporin antibiotic with effectiveness against most Gram-positive and Gram-negative bacteria. Commonly used to treat acute otitis media, pharyngitis, and sinusitis, cefpodoxime proxetil is a prodrug that is absorbed and de-esterified by the intestinal mucosa to Cefpodoxime.
Your doctor will decide the right dose of Cefpodoxime and will tell you how long to take your medicine. The number of Cefpodoxime tablets you need to take will depend on your condition. Follow your doctor’s instructions exactly and never change the dose yourself. Ask your doctor or pharmacist if you are unsure about how much medicine to take or when to take it.
The usual dose for adults
The usual adult dosage is Cefpodoxime 200mg-400mg in divided dose. If your doctor has prescribed one dose a day, it should be taken every 24 hours. If your doctor has prescribed two doses a day, each dose should be taken every 12 hours (you may find it convenient to take one dose in the morning and the other in the evening). The medicine should always be taken at the same time each day.
Elderly
For the elderly patients, the doses are the same as adults provided the kidney functions are normal.
Patients with kidney problems
The dosage of cefpodoxime does not require modification if creatinine clearance exceeds 40 ml/min. Below this value, pharmacokinetic studies indicate an increase in plasma elimination half-life and the maximum plasma concentrations, and hence the dosage should be adjusted appropriately.
There are insufficient data regarding the use of Cefpodoxime in children and adolescents with kidney problems. Cefpodoxime is therefore not recommended for use in these patients.
Hepatic Impairment:
The dosage does not require modification in cases of hepatic impairment.
Pediatric population:
Pediatric formulation of cefpodoxime is available for infants and children.
If you accidentally take too many tablets or a child swallows any Cefpodoxime tablets, contact your nearest hospital casualty department or your doctor immediately.
If you forget to take a tablet, take one as soon as you remember. However, if the next dose is due in less than 6 hours, skip the missed dose and go back to your regular dosing schedule. Do not take double doses.
Do not stop treatment early because it is important that you complete the FULL course of this medicine in order to reduce the chance of the infection returning.
If you have any further questions on the use of this product, ask your doctor or pharmacist.
Taking other medicines
Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.
In particular, tell your doctor or pharmacist if you are taking:
Cephalosporins potentially enhance the anticoagulant effect of coumarins and reduce the contraceptive effect of oestrogens.
Taking Cefpodoxime with food and drink
Cefpodoxime may be taken with or without food. You should swallow the tablets whole with a glass of water.
Like all medicines, Cefpodoxime can cause side effects, although not everybody gets them.
The following side effects are important and will require immediate action if you experience them. You should stop taking Cefpodoxime and see your doctor immediately if the following symptoms occur:
Rare side effects (affect less than 1 in 1,000 patients) include:
If severe or persistent diarrhea during or after therapy thought to be Pseudomembranous enterocolitis (rare in children)
Very rare side effects (affect less than 1 in 10,000 patients) include:
blood disorders (thrombocytosis, thrombocytopenia, leukopenia, neutropenia, agranulocytosis, eosinophilia, decreased hemoglobin values)bullous skin reactions and increase of uremic substance (creatinine and urea) in serum
Common side effects (affect less than 1 in 10 patients) include:
Stomach upset, nausea, vomiting, loss of appetite, bloating, or diarrhea. Bloody diarrhea may occur as a symptom of enterocolitis. Allergic reactions have been observed, mostly in the form of skin lesions with or without itching
Uncommon side effects (affect less than 1 in 100 patients) include:
Hemolytic anemia, Headache, tinnitus, paresthesias and dizziness, Asthenia, fatigue, and discomfort (malaise).Elevation of liver enzymes
Effect on laboratory tests
A false-positive reaction for glucose in the urine may occur with Benedict’s or Fehling’s solutions or with copper sulphate test tablets, but not with tests based on enzymatic glucose oxidase reactions. Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine.
Pregnancy and breast-feeding
If you are pregnant, likely to become pregnant or breastfeeding, you must tell your doctor before taking this medicine. Ask your doctor or pharmacist for advice before taking any medicine.
Driving and using machines
Cefpodoxime do not usually affect your ability to drive or use machines. However, if you feel light-headed or dizzy, do not drive or operate machinery.
Cefpodoxime can be used to treat:
Cefpodoxime is an oral third-generation cephalosporin antibiotic with effectiveness against most Gram-positive and Gram-negative bacteria. Commonly used to treat acute otitis media, pharyngitis, and sinusitis, cefpodoxime proxetil is a prodrug that is absorbed and de-esterified by the intestinal mucosa to Cefpodoxime.
Your doctor will decide the right dose of Cefpodoxime and will tell you how long to take your medicine. The number of Cefpodoxime tablets you need to take will depend on your condition. Follow your doctor’s instructions exactly and never change the dose yourself. Ask your doctor or pharmacist if you are unsure about how much medicine to take or when to take it.
The usual dose for adults
The usual adult dosage is Cefpodoxime 200mg-400mg in divided dose. If your doctor has prescribed one dose a day, it should be taken every 24 hours. If your doctor has prescribed two doses a day, each dose should be taken every 12 hours (you may find it convenient to take one dose in the morning and the other in the evening). The medicine should always be taken at the same time each day.
Elderly
For the elderly patients, the doses are the same as adults provided the kidney functions are normal.
Patients with kidney problems
The dosage of cefpodoxime does not require modification if creatinine clearance exceeds 40 ml/min. Below this value, pharmacokinetic studies indicate an increase in plasma elimination half-life and the maximum plasma concentrations, and hence the dosage should be adjusted appropriately.
There are insufficient data regarding the use of Cefpodoxime in children and adolescents with kidney problems. Cefpodoxime is therefore not recommended for use in these patients.
Hepatic Impairment:
The dosage does not require modification in cases of hepatic impairment.
Pediatric population:
Pediatric formulation of cefpodoxime is available for infants and children.
If you accidentally take too many tablets or a child swallows any Cefpodoxime tablets, contact your nearest hospital casualty department or your doctor immediately.
If you forget to take a tablet, take one as soon as you remember. However, if the next dose is due in less than 6 hours, skip the missed dose and go back to your regular dosing schedule. Do not take double doses.
Do not stop treatment early because it is important that you complete the FULL course of this medicine in order to reduce the chance of the infection returning.
If you have any further questions on the use of this product, ask your doctor or pharmacist.
Taking other medicines
Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.
In particular, tell your doctor or pharmacist if you are taking:
Cephalosporins potentially enhance the anticoagulant effect of coumarins and reduce the contraceptive effect of oestrogens.
Taking Cefpodoxime with food and drink
Cefpodoxime may be taken with or without food. You should swallow the tablets whole with a glass of water.
Like all medicines, Cefpodoxime can cause side effects, although not everybody gets them.
The following side effects are important and will require immediate action if you experience them. You should stop taking Cefpodoxime and see your doctor immediately if the following symptoms occur:
Rare side effects (affect less than 1 in 1,000 patients) include:
If severe or persistent diarrhea during or after therapy thought to be Pseudomembranous enterocolitis (rare in children)
Very rare side effects (affect less than 1 in 10,000 patients) include:
blood disorders (thrombocytosis, thrombocytopenia, leukopenia, neutropenia, agranulocytosis, eosinophilia, decreased hemoglobin values)bullous skin reactions and increase of uremic substance (creatinine and urea) in serum
Common side effects (affect less than 1 in 10 patients) include:
Stomach upset, nausea, vomiting, loss of appetite, bloating, or diarrhea. Bloody diarrhea may occur as a symptom of enterocolitis. Allergic reactions have been observed, mostly in the form of skin lesions with or without itching
Uncommon side effects (affect less than 1 in 100 patients) include:
Hemolytic anemia, Headache, tinnitus, paresthesias and dizziness, Asthenia, fatigue, and discomfort (malaise).Elevation of liver enzymes
Effect on laboratory tests
A false-positive reaction for glucose in the urine may occur with Benedict’s or Fehling’s solutions or with copper sulphate test tablets, but not with tests based on enzymatic glucose oxidase reactions. Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine.
Pregnancy and breast-feeding
If you are pregnant, likely to become pregnant or breastfeeding, you must tell your doctor before taking this medicine. Ask your doctor or pharmacist for advice before taking any medicine.
Driving and using machines
Cefpodoxime do not usually affect your ability to drive or use machines. However, if you feel light-headed or dizzy, do not drive or operate machinery.
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