1. In Treatment of Hypertension (high blood pressure): LASIMAX tablet helps to reduce blood pressure by preventing your body from absorbing excess salt, which is then excreted in your urine. Additionally, it helps eliminate excess water, making it easier for your heart to circulate blood. Lowering blood pressure reduces the risk of heart attack and stroke. For best results, take the medication regularly and adopt healthy lifestyle changes.
2. In Treatment of Edema: LASIMAX tablet increases urine production, helping your body to eliminate excess water. This alleviates symptoms like shortness of breath and swelling in your arms, legs, or abdomen, making daily activities easier and improving your confidence in being active. Regular use and appropriate lifestyle modifications enhance the effectiveness of this medicine.

Always take Frusemide tablets exactly as your doctor has instructed you. You should check with your doctor or pharmacist if you are not sure.

Taking this medicine: Swallow the tablets whole with a glass of water. If you feel the effect of your medicine is too weak or too strong, do not change the dose yourself, but ask your doctor .

Adults and elderly: The usual dose is one or two tablets first thing in the morning. Your doctor will tell you how many tablets to take.

Children and adolescents (under 18 years of age): Not recommended as safety in this age group has not yet been established.

Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines. In particular, you should tell your doctor if you are using medicines containing any of the following active substances:

Do not take this medicine, and tell your doctor, if you are taking:

• Medicines which change the amount of potassium in your blood. These include potassium supplements such as potassium chloride or certain water tablets (diuretics) such as triamterene.

The following medicines can affect the way Furosemide Tablets work and increase the chance of you getting side effects:

• Medicines called ‘ACE inhibitors’ like ramipril, enalapril, perindopril or losartan, candesartan, irbesartan (called ‘angiotensin II receptor antagonists’). Your doctor may need to change the dose of your tablets or ask you to stop taking them.
• Medicines for high blood pressure or heart problems. Your doctor may need to change the dose of your medicine.
• Medicines used to treat high blood pressure or prostate problems known as alpha-blockers, such as prazosin
• Other medicines used to treat high blood pressure and other medicines used to remove water from the body known as diuretics, such as amiloride, spironolactone, acetazolamide and metolazone
• Medicines used to treat unusual heart beats, such as amiodarone, disopyramide, flecainide, lidocaine, sotalol and mexiletine
• Medicines to help you sleep and relax such as chloral hydrate
• Medicines used as a general anesthetic for relaxing your muscles during surgery. If you are going to have an anesthetic please ensure that the doctor or nurse knows you are taking furosemide
• Medicines for diabetes. These may not work as well when you are taking Frusemide Tablets.
• Theophylline – used for wheezing or difficulty in breathing.
• Phenytoin – used for epilepsy. This can lower the effect of Furosemide Tablets.
• Medicines used for mental problems called ‘psychoses’, such as risperidone, amisulpride, sertindole, pimozide and chlorpromazine. Avoid using pimozide at the same time as furosemide

The following medicines can increase the chance of side effects when taken with Furosemide Tablets:

• Lithium – used for mental illnesses, Cisplatin – used for some cancers, Digoxin – used for heart problems. Your doctor may need to change the dose of your medicine, Non-steroidal anti-inflammatory drugs (NSAIDS) – used for pain and inflammation such as aspirin, ibuprofen, ketoprofen or indometacin, Carbamazepine – used for epilepsy, Aminoglutethimide – used for breast cancer.
• Medicine used to stop the rejection of organs after a transplant such as tacrolimus, ciclosporin, aldesleukin, Moxisylyte used to treat Raynaud’s syndrome, Medicines used to treat angina that you spray or dissolve under your tongue such as glyceryl trinitrate or isosorbide dinitrate, Methotrexate – used for cancers of the skin, joint or bowel diseases, Carbenoxolone and sucralfate – used for ulcers of the food pipe (gullet).

If you are taking sucralfate (a medicine for stomach ulcers): Do not take sucralfate at the same time as Frusemide Tablets. Take your dose at least 2 hours before or after Frusemide Tablets. This is because it can affect the way your medicine works.

Like all medicines Frusemide Tablets can cause side effects, although not everybody gets them. If any of the below mentioned side effects are observed please inform your doctor immediately:

• allergic reactions such as itching, skin rash with severe itching and nettle rash, fever, allergic to light, severe allergic reaction with (high) fever, red patches on the skin, joint pain and/or inflammation of the eyes, severe, acute (allergic) reaction accompanied by fever and blisters on the skin/peeling skin and tiny spots from bleeding in the skin.
• sudden inflammation of the pancreas accompanied by severe pain in the upper abdomen, shifting towards the back.

Common: Frusemide can cause an excessive depletion of bodily fluids (e.g. passing urine more often than normal) and minerals (sodium, potassium, magnesium, calcium). Symptoms that can occur are thirst, headache, confusion, muscle cramps, increased irritability of the muscles, muscular weakness, heart rhythm disturbances and gastrointestinal problems such as sensation of unease and discomfort in stomach with an urge to vomit, or diarrhoea.

If you have a shortage of sodium (sodium deficiency): cramp in the calf muscles, loss of appetite, listlessness, feeling of weakness, dizziness, drowsiness, confusion.

If you have a shortage of potassium (potassium deficiency): muscular weakness and the inability to contract one or more muscles (paralysis), increased excretion of urine, heart problems, in the case of severe potassium deficiency: interference with the function of the intestine or confusion, which can result in coma.

If you have a shortage of magnesium and calcium (magnesium and calcium deficiency): increased irritability of the muscles, heart rhythm disturbances, lowering of blood pressure, resulting in impaired concentration and reactions, light-headedness, a feeling of pressure in the head, headache, dizziness, drowsiness, a feeling of weakness, visual disturbances, dry mouth and an inability to stand upright

Uncommon: abnormal blood count accompanied by bruising and a tendency to bleed sensitivity to light (photosensitivity), involuntary leakage of urine, in the elderly, this can lead to a low blood volume, fluid depletion and thickening of the blood. This can cause clots to form in the blood, deafness (sometimes irreversible)

Rare: abnormal blood count (white blood cell deficiency) accompanied by a increased susceptibility to infection, increase in certain substances (eosinophilic cells) in the blood, a crawling sensation on the skin, itching or tingling without any reason, a life-threatening form of unconsciousness, hearing disorders & ringing in the ears. These disorders are usually temporary in nature, inflammation of a blood vessel, acute kidney failure.

Do not take Furosemide Tablets if:

• you are allergic (hypersensitive) to Frusemide. Signs of an allergic reaction include: a rash, swallowing or breathing problems, swelling of your lips, face, throat or tongue.
• you are allergic to amiloride, sulfonamides or sulphonamide derivatives, such as sulfadiazine or co-trimoxazole.
• you have been told by a doctor that you have kidney failure. In some types of kidney failure, it is still okay to have this medicine. Your doctor will be able to decide.
• you have severe liver problems (cirrhosis).
• your doctor has told you that you have a low blood volume or are dehydrated (with or without accompanying low blood pressure).
• you are not passing any water (urine).
• you have too little potassium or sodium in your blood (shown in blood test),
• you have an illness called ‘Addison’s Disease’. This can make you feel tired and weak
• you are breast-feeding
• you are taking other medicines which change the amount of potassium in your blood
• you are children and adolescents under 18 years of age. Furosemide tablets are not suitable for children.

Do not take Frusemide Tablets if any of the above apply to you. If you are not sure, talk to your doctor or pharmacist before taking Frusemide Tablets.

Warnings and precautions:

Talk to your doctor, pharmacist or nurse before taking Furosemide Tablets if you:

• you have low blood pressure or feel dizzy when you stand up.
• you are taking digoxin, used to treat heart problems
• you have diabetes
• you are elderly, if you are on other medications which can cause the drop the blood pressure and if you have other medical conditions that are risks for the drop of blood pressure
• you have difficulty in passing water (urine)
• you have low levels of protein in your blood
• you suffer from acute porphyria symptoms of which may include severe stomach, back or thigh pain. Nausea, vomiting or constipation may also present along with weakness in arms and legs.
• you have liver or kidney problems
• you are an elderly patient with dementia and are also taking risperidone
• you have prostate problems
• you have gout
• you feel dizzy or dehydrated. This can happen if you have lost a lot of water through being sick, having diarrhoea or passing water very often. It can also happen if you are having trouble drinking or eating
• you are going to give this medicine to a baby that was born too early
• you are going to have a glucose test
• you are taking any other water tablets

Frusemide tablets with food, drink and alcohol: You should avoid drinking alcohol while taking Frusemide tablets as this may lower your blood pressure further.

Pregnancy and breast-feeding: Do not take Frusemide Tablets if you are pregnant. Talk to your doctor before taking this medicine if you are pregnant, might become pregnant, or think you might be pregnant. Do not breast-feed if you are taking Frusemide Tablets. This is because small amounts may pass into the mothers milk. Talk to your doctor before taking this medicine if you are breast-feeding or planning to breast-feed. Ask your doctor or pharmacist for advice before taking any medicine if you are pregnant or breastfeeding.

Driving and using machines: You may feel dizzy or unwell after taking Frusemide Tablets. If this happens, do not drive or use any tools or machines.